Best Berberine Supplements For Metabolic Health & Weight Loss

Suvrat Singh
Best Berberine Supplement - Theislandnow

Looking for a way to boost your health? Let’s discuss berberine, a potent plant extract long used in traditional medicine for its various health benefits, free from the complexities of conventional drugs. 


The berberine supplements contain alkaloids renowned for their health-enhancing properties, such as managing conditions, regulating blood sugar levels, supporting gut health, aiding in weight loss, and more.


However, with the huge range of berberine supplements available online, not all deliver as promised. That’s why we’ve sifted through to find the best berberine supplements of 2024.


We’ll look into each recommended supplement extensively, giving you all the necessary information. Go through this detailed guide to find a berberine supplement that matches your health objectives.

We will go on and look into each product more deeply and provide you with all of the necessary information so that you can make the best choice and buy the right supplement.

7 Best Berberine Supplements Of 2024

  1. Riti – Overall Best Berberine Supplement, Editor’s Pick 
  2. BerbaPrime  – Vegan-Friendly Berberine Supplement
  3. Berberine Pure +  – Best Berberine Supplement For Lowering Cholesterol
  4. Berberine HCL – Most Popular Berberine Powder For Weight Loss
  5. Berbamax – Best Berberine Supplement For Healthy Metabolism
  6. Berberine Root Extract – Highly Rated Berberine Supplement For Healthy Blood Sugar Levels
  7. Berberine-500 – Recommended Berberine Supplements For Better Heart Health

Overall Best Berberine Supplement, Editor’s Pick


Riti’s Berberine Capsules are the best supplement on the market. They are purely made from Berberine HCI and contain no other fillers, contaminants, or impurities. The brand recommends you take 2 capsules a day, and for best results, take them 20-30 minutes before lunch or dinner with an 8 fl oz glass of water. Thus, they fit seamlessly into your daily fitness routine. 


These capsules are multi-beneficial, helping you maintain healthy blood sugar levels, supporting lipid metabolism, promoting heart health, and reducing sugar cravings. They are super affordable, starting at just $44.95, and have a fast 2-day delivery, so you don’t have to wait long to get your  Berberine Capsules. 


Riti offers its Berberine Capsules in 3 convenient sizes, fitting into the budgets of all pockets. You can buy 1 pack if you want to try the product for $44.95 or 2 or 3 packs if you want to restock. Buying 2 packs will cost you $80.91, and you can save almost $10, while their 3 pack is priced at $114.62 and can help you pocket $20. 


Each bottle contains 60 capsules with 1200mg of Berberine HCl per serving. The best part is that you can save 25% if you subscribe to their recurring monthly order. It is 100% natural and safe for everyday use, so be assured about the quality of the product. 

Customer Reviews

Ritis Berberine Capsules have garnered rave reviews from satisfied customers who praise the product’s effectiveness. They credit its success to promoting better health, stabilizing blood sugar levels, and enhancing overall well-being. Due to these beneficial effects and positive results, they plan to continue using it for their health and wellness needs.

#2 BerbaPrime – Vegan-Friendly Berberine Supplement


BerbaPrime is one of the best Berberine supplements for vegans, as it is purely made from the plant-based alkaloid. It works on the 3 most important areas of health improvement, including maintaining healthy metabolism, cholesterol, and blood sugar. They have full-proof evidence of the product’s effectiveness, so you can choose this supplement for your wellness. 


The product might be slightly pricey, but worth your money. 1 bottle containing 90 veggie capsules costs $59.99. However, buying their 2 bottles will cost you $99.98, but you will also get 1 bottle for free, which is $80 off. On buying 3 bottles, you get 2 bottles for free. 


BerbaPrime is made using natural and powerful plant-based alkaloid that offers various health benefits. The product has passed the lab tests, meaning it contains no harmful chemicals, artificial colorings, or other impurities. 


The product contains 90 capsules with 500mg of Berberine HCL per capsule. A single bottle will last you a month. Though the starting range of the product is $59.99, you save max if you go for their 3 bottles as you get 2 bottles just for free. 



  • Safe and Cruelty-free.
  • Supports blood sugar levels.
  • Made in GMP-certified facilities.
  • Free shipping within the US.
  • Offers a money-back guarantee.


  • Slightly expensive 

Customer Reviews

Customers value BerbaPrime for its efficiency and ethical production methods. They frequently mention the effects on their metabolism and blood sugar levels, showing contentment with the vegan supplement’s composition. It’s more than a supplement; to many, it signifies a move towards a more conscientious lifestyle.

#3. Berberine Pure +  – Best Berberine Supplement For Lowering Cholesterol

Berberine Pure

Nuzena’s Berberine Pure + is made in FDA-regulated facilities from all-natural ingredients. This supplement is suitable for both men and women. It can help with high cholesterol and regulate blood sugar levels and metabolism.

These pills help you activate an enzyme inside your cells which is called AMP-activated protein kinase (AMPK). This enzyme plays a significant role in your body since it regulates your metabolism and is found in the cells of various organs. For example, the AMPK can be found in the brain, heart, liver, and kidneys.

According to a recent study, Berberine works by inhibiting an enzyme called PCSK9, which removes LDL from the bloodstream. This process maintains the healthy cholesterol in your body. Furthermore, it can break down the carbohydrates in the gut. This can help the gut to increase its good bacteria.


Orders process within two to three business days. USPS Standard shipping should arrive within three to five business days. International orders typically arrive within seven to ten business days. All shipping information and confirmation are sent to your email. Nuzena also partners with Amazon Prime, so their product can be purchased through Prime to take advantage of their expedited shipping. Orders can be paid for using PayPal or your VISA, Mastercard, Discover, or American Express card.

One of their highlights is that you can easily promote the product as an affiliate if you are an influencer, use social media like Facebook, Instagram, and Twitter, and have an audience interested in a healthy lifestyle and fitness. Then, you need to contact Nuzena, who will provide you with more content on how to start working with them.

If the order is at default, or there is a problem, the company can easily replace the order and send you a new product. Furthermore, you can easily return the damaged product since it will give you the information you will receive in the package. The best part is that all this is free of charge.


  • Clinically proven ingredients
  • Non-GMO
  • Gluten-Free
  • Supports heart health
  • Improves metabolism and lipid bundles
  • Good manufacturing practices


  • Results may take 90 days to manifest

Customer Reviews

According to our research, there is 99% positive feedback regarding this product.

Most users have experienced increased energy which helped them to complete their daily tasks. The product can also help you if you are experiencing brain fog, which is a great plus.

Users love this product, and they state that they will recommend the product to their friends and family members.

The customer’s packaging arrived on time with no delays or damaged products. Nuzena’s customer support team was also lauded for their fast and helpful responses.

#4. Berberine HCL – Most Popular Berberine Powder For Weight Loss

Berberine HCL

Berberine HCL, made by Bulk Supplements, is found in Goldenseal, Oregon Grape, Barberry, and Golden-Thread. It can be used orally, or it can be applied topically to the skin as well. It is designed to help with digestion problems, reducing fat cells, lower blood pressure, lowering cholesterol levels and to reduce blood glucose levels, all of which can be achieved if you keep a healthy diet and exercise.

You can get it in different sizes 25 Grams (0.9 oz), 50 Grams (1.8 oz), 250 Grams (8.8 oz), 500 Grams (1.1 lbs), 1 Kilogram (2.2 lbs), 5 Kilograms (11 lbs), and 25 Kilograms (55 lbs).

You can take HCL Berberine as a dietary supplement. Take 500 mg once or twice a day or as directed by your PCP as clinical research is still underway for berberine and its potential benefits.


The brand ships its products from the United States. Domestic orders over $49 ship free. Shipments outside their borders might be subject to customs duties and taxes you will be responsible for. The company also advises you to double-check with your local customs office and check if the product is banned in your country.

Unopened products can be returned within 30 days of the invoice for a full refund. Opened orders may be eligible for a partial refund. Shipping charges or discount codes you might have used will not be refunded. They provide free shipping on orders above $59.


  • Promotes heart, vision, and bone health
  • Supports liver function
  • Aids digestion
  • It helps maintain healthy glucose levels in already healthy people
  • Free U.S. shipping on orders over $49
  • 30-day return policy


  • It may cause constipation or nausea.

Customer Reviews

According to product reviews, customers are completely satisfied with the product and rated it high quality. They will continue using the product in the future as they have experienced the health benefits of it.

#5. Berbamax – Best Berberine Supplement For Healthy Metabolism


The berberine supplement, Berbamax lowers cholesterol and blood sugar. Diabetes is an illness that slowly ruins the body from the inside out by targeting each organ. The main component of this supplement, Berberine HCL, found in Berbamax, has been used by the Chinese for thousands of years to treat several health conditions, including type 2 diabetes. Other ingredients such as magnesium stearate, enhance this berberine supplement and provide potential benefits like lowering blood sugar levels, weight loss, maintain healthy blood sugar, help glucose metabolism and also support cardiovascular health.

You can get your hands on this supplement from their official website and choose between 1 month, 3 months & 5 months supply. We recommend going for the 1 month supply if you are trying this supplement for the first time.


The company ships its goods internationally from the US. For over $49 in domestic orders, shipping is free. However, customs charges and taxes may apply to shipments outside their boundaries, and you will be responsible for paying them. The business also suggests you confirm with your local customs office to see if the item is prohibited in your nation.

Unopened products may be returned within 30 days of the invoice for a full refund. A partial refund may be available for opened orders. You wouldn’t get your money back if you paid for shipping or use discount codes.


  • Promotes heart, vision, and bone health
  • Supports liver function
  • Aids digestion
  • It helps maintain healthy glucose levels in already healthy people


  • It may cause constipation or nausea.

Customer Reviews

Customers have expressed 100% satisfaction with the product in reviews and given it a high-quality rating. Given that they have already benefited from the product’s health advantages, such as a healthy digestive system, improvement in blood glucose levels, support in cardiovascular health and helping with overall gut health, they intend to keep using it in the future.

#6. Berberine Root Extract – Highly Rated Berberine Supplement For Healthy Blood Sugar Levels

Berberine Root Extract

Berberine Root Extract, Advanced Formula, is manufactured in the United States in Salt Lake City, Utah. It is manufactured by the famous company Solaray which has existed for more than four decades, and its products are distributed in over 60 countries.

The product formula can help you in many ways, starting with supporting your active lifestyle, metabolism, and overall wellness. So if you have any health issues, this product will get you back on track with your healthy lifestyle.


This product is also suitable for those following the ketogenic diet because Berberine can greatly support their metabolic support concerning ketones, glucose storage, and fatty acids. In addition, Berberine is made to support your AMPK activation, which can benefit everyone, not only those who follow the ketogenic diet.

Berberine Root Extract, Advanced formula, is tested in a lab and is non-GMO and vegan-friendly.

The company offers free delivery on orders that are over $50. In addition, they provide international shipping in more than 185+ countries. Besides, if you are unsatisfied with the Berberine Root Extract Advanced Formula, you can request a refund or replacement of the product within 60 days of your purchase.


  • Vegan-friendly
  • Non-GMO
  • It helps blood sugar control
  • Improves cardiovascular health, arthritis, and overall wellness
  • It may reduce symptoms associated with menstrual problems
  • Free shipping on orders over $49
  • 60-day return policy


  • It may cause constipation or an upset stomach.

Customer Reviews

Most customers reported being satisfied with just their first bottle of pills. However, many female customers are delighted with the product since it helps them with their menstrual cycles and immediately experience stabilizing effects of Berberine.

Some customers also used the product to help them with H. Pylori; the pills helped quickly. However, they also stated that they had not used any antibiotic to help them, only the Berberine Root Extract, Advanced Formula.

Moreover, many customers gave positive feedback because this product helped them regulate their blood pressure.

#7. Berberine-500 – Recommended Berberine Supplements For Better Heart Health


Berberine-500 is produced by the reputable brand Thorne. This product is a powerful botanical supplement that can help with your heart health and immune system. In addition, it may help users maintain a healthy respiratory tract, mucus membranes, and GI system. In turn, a supported GI system will produce beneficial bacteria in the gut and support weight loss and management.

Thorne’s Berberine-500 is made from natural ingredients and has no added flavors, colors, or sweeteners. Other ingredients include Calcium Laurate and a Hypromellose capsule.


The product is completely dairy-free, soy-free, and gluten-free. In addition, the company offers same business day shipping as long as you place your order before 12:00 pm Eastern time, Monday through Friday. Unfortunately, there is no weekend service.

Furthermore, a great feature is that their packaging is made of recycled materials.

Healthcare providers can expect to receive orders within one or two business days, and patients can expect to receive them within two to ten business days.

Thorne offers international shipping, usually taking around four weeks for delivery outside the U.S.


  • Supports heart and gut health
  • Improves metabolism
  • It may aid in weight loss
  • Maintains healthy respiratory tract mucus membranes
  • Free Shipping on orders in US
  • 60-day money-back guarantee
  • Good manufacturing practices


  • Does not ship to P.O. boxes

Customer Reviews

Customers state that this product helped to lower their cholesterol. Moreover, this product reportedly helped diabetic patients lower their blood sugar levels without exercise or activities.

Many happy buyers lose a lot of unnecessary fat cells just by using the product and doing nothing else. As they state, this product has changed their lives for the better. Overall this product is great, and it helps in many ways to stay healthy and active. In addition, all the customers received their products on time, and there were no delays.s

Berberine Benefits For Consumption

Berberine, a substance found in supplements such as Berberine HCL, Sunergetic Berberine, Solaray Berberine, Berberine 500, and Berberine Pure +, is widely recognized for its health benefits. It is considered safe for consumption and offers wellness advantages across different aspects of health.


  • Managing Weight – Berberine can support weight loss by boosting metabolism and regulating hormones.


  • Balancing Blood Sugar – It helps lower blood sugar levels for individuals with diabetes or at risk.


  • Controlling Cholesterol – Research suggests that Berberine may reduce LDL ( cholesterol) levels, promoting heart health.


  • Preventing Heart Disease – Berberine may help lower the risk of heart disease by affecting cholesterol and blood sugar levels.


  • Enhancing Mood – Initial studies hint at the mood-improving effects of Berberine in reducing symptoms of depression; further research is needed to confirm this benefit.


  • Increasing Insulin Sensitivity – It improves insulin sensitivity by assisting the body in utilizing insulin and maintaining blood sugar levels.

Buying Guide: Factors To Consider Before Buying Berberine Supplement

We have checked every brand that contains the Berberine and cut our list to the favorite Berberine supplement brands, and we checked each brand for the following, and this is what you should consider before purchasing berberine supplements.

  • Effectiveness of the Berberine pills

The best berberine supplement brands has been used in China and India for many years to treat different diseases. Currently, it is being used by thousands of satisfied customers.

They are effective overall, and they have many positive benefits. They can help you with your overall health. Most importantly, they can help you reduce high blood pressure, reduce brain fog, and improve your metabolism.

  • Efficient in treating PCOS using Berberine pills

Research is being done to see if the Berberine supplement options can be a good treatment for patients with polycystic ovarian syndrome.

It has been observed that it is effective since it helps with high blood pressure, high cholesterol, overweight, and diabetes. All PCOS patients are experiencing all of these mentioned symptoms because of the change in their hormones and metabolism.

  • Efficient in treating Cancer using Berberine pills

According to the research done in cancer cell laboratories, it has been proven that Berberine can help with ovarian cancer, prostate cancer, colorectal cancer, lung cancer, liver cancer, and cervical cancer.

It has been proven that they can reduce the risk of getting cancer and all the symptoms cancer can cause.

  • Ingredients of the Berberine pills

The Berberine pills are all made of natural compounds. Berberine is found in some trees, such as Oregon Grape and Phellodendron. Goldenseal, European barberry, and Turmeric Tree as well. It has a yellow color, and it has a bitter taste.

  • Clinical tests and research done on Berberine pills

There is some research done, and it is proven that the pills are all safe to consume. However, sometimes they can also act as a prescription drug, so you should see your PCP before taking this supplement.

According to the Association for the Advancement of Restorative Medicine, Berberine supplements can reduce blood glucose and insulin resistance in patients who have type 2 Diabetes.

  • Adverse side effects and their severity 

According to the research that multiple research centers did, it is proven that there are no side effects of using Berberine products.

Remember that Berberine products can lower your blood sugar levels, help with cholesterol levels so if you already have low blood sugar, contact your doctor before taking any of the Berberine pills.

  • Interaction with other medicines 

According to the researchers, taking Berberine with some medication that can slow clotting might increase your chances of bruising.

But it has been shown that they do not interact with other prescribed drugs.

If you are taking different medications and have multiple heart conditions or maybe problems with your sugar level, make sure you contact your doctor before taking the supplement.

  • Harmful ingredients

Since these products are made out of organic substances, it is completely safe to use them, and they have no harmful ingredients.

  • Customer’s reviews

We have researched, showing that the customers are extremely satisfied with using the products.

Overall there is only positive feedback, and more than 1000 satisfied customers have been using the pills for months and years.

Furthermore, they are completely satisfied with the consumer care support for each brand of the above-mentioned Berberine products.

  • Recommended Dosage & Usage

Each product has instructions for use that are written on the bottle.

  1. Berberine HCL: You can take 500 mg once or twice daily or as instructed by your physician.
  2. Sunergetic Berberine: You can take two capsules daily or as instructed by your physician.
  3. Solaray Berberine: You can take one Vegcup daily with your meal, with a glass of water, or as instructed by your physician.
  4. Berberine-500: You can take two capsules daily or as instructed by your physician.
  5. Nuzena Berberine+: You can take 2 capsules a day. The best time to take them is before your meals or as instructed by your physician.

  • Prescription 

You don’t need a prescription to buy the Berberine supplement. You can get any of these pills over the counter or order them online.

Consult with your PCP or a healthcare worker before taking any Berberine supplements. And also, make sure you discuss your current and past medical history with your current PCP.

Who should not take Berberine?

It’s not recommended to take Berberine when you’re pregnant. When breastfeeding, it can cross the placenta and potentially cause issues like Kernicterus, a type of brain injury in newborns. If an infant has jaundice, which causes yellowing of the skin due to high bilirubin levels, Berberine could exacerbate their health conditions and even play a role in the onset of hepatitis and tumors.

FAQs On Berberine Supplement

If you want to see any results, take the Berberine pills around 3 or 4 weeks before noticing any changes.

According to customer reviews, it usually takes three weeks for any positive effect or changes in cholesterol levels, weight gain or reduce blood sugar levels to be noticed. Moreover, it depends on your type of health condition and your age and current health.

According to the studies, there are no severe side effects if you use too much Berberine. This berberine supplement can only help you regulate your blood sugar, hormone levels, and possible heart diseases. It can also treat some metabolic problems, including diabetes and obesity. You can only expect great results, and there is no risk of taking too much Berberine.

Make sure to carefully read the instructions on the package and follow the guidelines for the products you use. These instructions will explain how and when to use them effectively. When it comes to Berberine capsules, it’s recommended not to consume two or three capsules simultaneously during a meal as this may lessen their effectiveness and offer no additional benefits.

Polycystic Ovary Syndrome (PCOS) is a condition in women characterized by increased levels of hormones, which can result in fertility issues and raise the chances of high cholesterol, high blood pressure, and obesity. Berberine supplements are suggested as they share similarities with prescription medications for addressing PCOS, and research has indicated their effectiveness as a treatment choice.

Research carried out in cancer research centers has revealed that Berberine, with its influence on molecular-level operations, shows promise in fighting various cancer types, such as ovarian, prostate, colorectal, lung, liver, and cervical cancer. Studies indicate that Berberine impedes cancer progression and contributes to cell destruction. It’s worth mentioning that these findings are based on lab experiments and await validation through clinical trials involving participants.

Metformin is a drug that helps reduce blood sugar levels for individuals with glucose regulation issues. Yet, research indicates that Berberine supplements may be more effective than Metformin because of their natural ingredients and wider advantages. Berberine’s ability to activate AMPK faster allows cells to absorb glucose and lipids more efficiently for energy, positioning it as a better choice for controlling blood sugar levels.

Pure Berberine HCL is the most potent form of Berberine. People bank on this to aid them with weight loss, insulin resistance, lower blood sugar levels, and an overall improvement in the immune system.

Most berberine supplements work differently and you should always check your berberine supplements label to determine whether taking berberine supplements is your cup of tea or not.

Conclusion: What Is The Best Quality Berberine Supplement On The Market?

In conclusion, all of the Berberine supplements that we reviewed, Riti, BerbaPrime, Berberine HCL, Synergetic Berberine, Solaray, Berberine-500, and Berberine Pure +, are all-natural remedies that can help you in many ways with your health.

Overall, Berberine Products can help you with high blood pressure, overall wellness, arthritis, and cardiovascular health and helps cancer patients and women with Polycystic ovary syndrome or metabolic syndrome.

We hope that this article provides you with the best information you can get out there on the web regarding the Berberine supplements. We have done the research, and we hope that we can help you get the motivation today to buy some of the reviewed Berberine supplements that can provide you with great results and help you in the best ways possible.

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