Best Berberine Supplement Brands Of 2024

Juhi Dutta  - Content Editor At The Island Now
Best Berberine Supplement - Theislandnow

Berberine is a bioactive compound and the most used one when it comes to traditional medicines. According to a survey, it also has the potential to control cholesterol and blood sugar levels.  It has a long history of use in traditional Chinese medicine and Indian medicine for the human body. It belongs to medicines called alkaloids, which are natural organic compounds that don’t contain nitrogen. Moreover, it includes only non-acidic components. The best berberine supplement contains all these qualities and more.


According to modern science, this supplement is excellent for helping those who have chronic illnesses. It can cause a significant reduction in blood sugar levels, helps with creating good gut bacteria, help you lose weight, and has many more health benefits.

However, many companies pay for their Berberine product to be shown and promoted on the web while their ingredients and effectiveness may be unsafe or untested. 


We made our list of the best Berberine supplements of 2023 so that you can stop relying on false information and get the best brands and products.


We will go on and look into each product more deeply and provide you with all of the necessary information so that you can make the best choice and buy the right supplement.

5 Best Berberine Supplements Of 2023

  1. Berbamax – Overall Best Berberine Supplement, Editor’s Pick 
  2. Berberine HCL – Most Popular Berberine Powder For Weight Loss 
  3. Berberine Root Extract – Highly Rated For Healthy Blood Sugar Levels
  4. Berberine-500 – Recommended Berberine Supplements For Better Heart Health
  5. Berberine Pure +  – Best Herbal Supplement For Lowering Cholesterol

#1. Berbamax – Overall Best Berberine Supplement, Editor’s Pick 

The berberine supplement, Berbamax lowers cholesterol and blood sugar. It also contains ingredients to improve digestive enzymes. The main component of this supplement, Berberine HCL, found in Berbamax, has been used by the Chinese for thousands of years to treat several health conditions, including type 2 diabetes. Other ingredients such as magnesium stearate, enhance this berberine supplement and provides potential benefits like lowering blood sugar levels, weight loss, maintain healthy blood sugar, help glucose metabolism and also support cardiovascular health.

You can get your hands on this supplement from their official website and choose between 1 month, 3 months & 5 months supply. We recommend going for the 1 month supply if you are trying this supplement for the first time.


The company ships its goods internationally from the US. For over $49 in domestic orders, shipping is free. However, customs charges and taxes may apply to shipments outside their boundaries, and you will be responsible for paying them. The business also suggests you confirm with your local customs office to see if the item is prohibited in your nation.


Unopened products may be returned within 30 days of the invoice for a full refund. A partial refund may be available for opened orders. You wouldn’t get your money back if you paid for shipping or use discount codes.



  • Promotes heart, vision, and bone health
  • Supports liver function
  • Aids digestion
  • It helps maintain healthy glucose levels in already healthy people



  • It may cause constipation or nausea.

Customer Reviews

Customers have expressed 100% satisfaction with the product in reviews and given it a high-quality rating. Given that they have already benefited from the product’s health advantages, such as healthy digestive system, improvement in blood glucose levels, support in cardiovascular health and helping with overall gut health, they intend to keep using it in the future.

#2. Berberine HCL – Most Popular Berberine Powder For Weight Loss 

Berberine HCL, made by Bulk Supplements, is found in Goldenseal, Oregon Grape, Barberry, and Golden-Thread. One of the best probiotic supplement, it can be used orally, or it can be applied topically to the skin as well. It is designed to help with digestion problems, reducing fat cells, lower blood pressure, lowering cholesterol levels and to reduce blood glucose levels, all of which can be achieved if you keep a healthy diet and exercise.

You can get it in different sizes 25 Grams (0.9 oz), 50 Grams (1.8 oz), 250 Grams (8.8 oz), 500 Grams (1.1 lbs), 1 Kilogram (2.2 lbs), 5 Kilograms (11 lbs), and 25 Kilograms (55 lbs).


You can take HCL Berberine as a dietary supplement. Take 500 mg once or twice a day or as directed by your PCP as clinical research is still underway for berberine and its potential benefits.


The brand ships its products from the United States. Domestic orders over $49 ship free. Shipments outside their borders might be subject to customs duties and taxes you will be responsible for. The company also advises you to double-check with your local customs office and check if the product is banned in your country.


Unopened products can be returned within 30 days of the invoice for a full refund. Opened orders may be eligible for a partial refund. Shipping charges or discount codes you might have used will not be refunded. They provide free shipping on orders above $59.



  • Promotes heart, vision, and bone health
  • Supports liver function
  • Aids digestion
  • It helps maintain healthy glucose levels in already healthy people
  • Free U.S. shipping on orders over $49
  • 30-day return policy



  • It may cause constipation or nausea.

Customer Reviews

According to product reviews, customers are completely satisfied with the product and rated it high quality. They will continue using the product in the future as they have experienced the health benefits of it.

#3. Berberine Root Extract – Highly Rated For Healthy Blood Sugar Levels

Berberine Root Extract, Advanced Formula, is manufactured in the United States in Salt Lake City, Utah. It is manufactured by the famous company Solaray which has existed for more than four decades, and its products are distributed in over 60 countries.


The product formula can help you in many ways, starting with supporting your active lifestyle, metabolism, and overall wellness. So if you have any health issues, this product will get you back on track with your healthy lifestyle.


This product is also suitable for those following the ketogenic diet because Berberine can greatly support their metabolic support concerning ketones, glucose storage, and fatty acids. In addition, Berberine is made to support your AMPK activation, which can benefit everyone, not only those who follow the ketogenic diet.


Berberine Root Extract, Advanced formula, is tested in a lab and is non-GMO and vegan-friendly.

The company offers free delivery on orders that are over $50. In addition, they provide international shipping in more than 185+ countries. Besides, if you are unsatisfied with the Berberine Root Extract Advanced Formula, you can request a refund or replacement of the product within 60 days of your purchase.



  • Vegan-friendly
  • Non-GMO
  • It helps blood sugar control
  • Improves cardiovascular health, arthritis, and overall wellness
  • It may reduce symptoms associated with menstrual problems
  • Free shipping on orders over $49
  • 60-day return policy



  • It may cause constipation or an upset stomach.

Customer Reviews

Most customers reported being satisfied with just their first bottle of pills. However, many female customers are delighted with the product since it helps them with their menstrual cycles and immediately experience stabilizing effects of Berberine.


Some customers also used the product to help them with H. Pylori; the pills helped quickly. However, they also stated that they had not used any antibiotic to help them, only the Berberine Root Extract, Advanced Formula.


Moreover, many customers gave positive feedback because this product helped them regulate their blood pressure.

#4. Berberine-500 – Recommended Berberine Supplements For Better Heart Health

Berberine-500 is produced by the reputable brand Thorne. This product is a powerful botanical supplement that can help with your heart health and immune system. In addition, it may help users maintain a healthy respiratory tract, mucus membranes, and GI system. In turn, a supported GI system will produce beneficial bacteria in the gut and support weight loss and management.


Thorne’s Berberine-500 is made from natural ingredients and has no added flavors, colors, or sweeteners. Other ingredients include Calcium Laurate and a Hypromellose capsule.


The product is completely dairy-free, soy-free, and gluten-free. In addition, the company offers same business day shipping as long as you place your order before 12:00 pm Eastern time, Monday through Friday. Unfortunately, there is no weekend service.


Furthermore, a great feature is that their packaging is made of recycled materials.

Healthcare providers can expect to receive orders within one or two business days, and patients can expect to receive them within two to ten business days.


Thorne offers international shipping, usually taking around four weeks for delivery outside the U.S.



  • Supports heart and gut health
  • Improves metabolism
  • It may aid in weight loss
  • Maintains healthy respiratory tract mucus membranes
  • Free Shipping on orders in US
  • 60-day money-back guarantee
  • Good manufacturing practices



  • Does not ship to P.O. boxes

Customer Reviews

Customers state that this product helped to lower their cholesterol. Moreover, this product reportedly helped diabetic patients lower their blood sugar levels without exercise or activities.


Many happy buyers lose a lot of unnecessary fat cells just by using the product and doing nothing else. As they state, this product has changed their lives for the better. Overall this product is great, and it helps in many ways to stay healthy and active. In addition, all the customers received their products on time, and there were no delays.

#5. Berberine Pure +  – Best Herbal Supplement For Lowering Cholesterol

Nuzena’s Berberine Pure + is made in FDA-regulated facilities from all-natural ingredients. This supplement is suitable for both men and women. It can help with high cholesterol and regulate blood sugar levels and metabolism.


These pills help you activate an enzyme inside your cells which is called AMP-activated protein kinase (AMPK). This enzyme plays a significant role in your body since it regulates your metabolism and is found in the cells of various organs. For example, the AMPK can be found in the brain, heart, liver, and kidneys.

According to a recent study, Berberine works by inhibiting an enzyme called PCSK9, which removes LDL from the bloodstream. This process maintains the healthy cholesterol in your body. Furthermore, it can break down the carbohydrates in the gut. This can help the gut to increase its good bacteria.


Orders process within two to three business days. USPS Standard shipping should arrive within three to five business days. International orders typically arrive within seven to ten business days. All shipping information and confirmation are sent to your email. Nuzena also partners with Amazon Prime, so their product can be purchased through Prime to take advantage of their expedited shipping. Orders can be paid for using PayPal or your VISA, Mastercard, Discover, or American Express card.


One of their highlights is that you can easily promote the product as an affiliate if you are an influencer, use social media like Facebook, Instagram, and Twitter, and have an audience interested in a healthy lifestyle and fitness. Then, you need to contact Nuzena, who will provide you with more content on how to start working with them.

If the order is at default, or there is a problem, the company can easily replace the order and send you a new product. Furthermore, you can easily return the damaged product since it will give you the information you will receive in the package. The best part is that all this is free of charge.



  • Clinically proven ingredients
  • Non-GMO
  • Gluten-Free
  • Supports heart health
  • Improves metabolism and lipid bundles
  • Good manufacturing practices



  • Results may take 90 days to manifest

Customer Reviews

According to our research, there is 99% positive feedback regarding this product.


Most users have experienced increased energy which helped them to complete their daily tasks. The product can also help you if you are experiencing brain fog, which is a great plus.


Users love this product, and they state that they will recommend the product to their friends and family members.


The customer’s packaging arrived on time with no delays or damaged products. Nuzena’s customer support team was also lauded for their fast and helpful responses.

Berberine Benefits For Consumption

The Berberine Supplements in this article, Berberine HCL, Sunergetic Berberine, Solaray Berberine, Berberine-500, and Berberine Pure +, are entirely safe to use and may induce different health benefits.


Berberine health benefits may include weight loss, lower blood glucose levels, lower cholesterol, and lower your risk of heart disease. There is also some evidence to suggest it may help with depression. Clinical research is still being done to provide more information on this compound and other berberine supplements.

Berberine has also been shown to have a positive effect on insulin sensitivity, which is the ability of the body to respond to insulin and regulate blood sugar levels. These health benefits are potential and cannot be determined to be true but as berberine appears to be aiding these exact benefits in some individuals, there is still intense research going on.

Buying Guide: Factors To Consider Before Buying Berberine Supplement

We have checked every brand that contains the Berberine and cut our list to the favorite Berberine supplement brands, and we checked each brand for the following, and this is what you should consider before purchasing berberine supplements.

The best berberine supplement brands has been used in China and India for many years to treat different diseases. Currently, it is being used by thousands of satisfied customers.


They are effective overall, and they have many positive benefits. They can help you with your overall health. Most importantly, they can help you reduce high blood pressure, reduce brain fog, and improve your metabolism.

Research is being done to see if the Berberine supplement options can be a good treatment for patients with polycystic ovarian syndrome.


It has been observed that it is effective since it helps with high blood pressure, high cholesterol, overweight, and diabetes. All PCOS patients are experiencing all of these mentioned symptoms because of the change in their hormones and metabolism.

According to the research done in cancer cell laboratories, it has been proven that Berberine can help with ovarian cancer, prostate cancer, colorectal cancer, lung cancer, liver cancer, and cervical cancer.


It has been proven that they can reduce the risk of getting cancer and all the symptoms cancer can cause.

The Berberine pills are all made of natural compounds. Berberine is found in some trees, such as Oregon Grape and Phellodendron. Goldenseal, European barberry, and Turmeric Tree as well. It has a yellow color, and it has a bitter taste.

There is some research done, and it is proven that the pills are all safe to consume. However, sometimes they can also act as a prescription drug, so you should see your PCP before taking this supplement.


According to the Association for the Advancement of Restorative Medicine, Berberine supplements can reduce blood glucose and insulin resistance in patients who have type 2 Diabetes.

According to the research that multiple research centers did, it is proven that there are no side effects of using Berberine products.


Remember that Berberine products can lower your blood sugar levels, help with cholesterol levels so if you already have low blood sugar, contact your doctor before taking any of the Berberine pills.

According to the researchers, taking Berberine with some medication that can slow clotting might increase your chances of bruising.

But it has been shown that they do not interact with other prescribed drugs.


If you are taking different medications and have multiple heart conditions or maybe problems with your sugar level, make sure you contact your doctor before taking the supplement.

Since these products are made out of organic substances, it is completely safe to use them, and they have no harmful ingredients.

We have researched, showing that the customers are extremely satisfied with using the products.


Overall there is only positive feedback, and more than 1000 satisfied customers have been using the pills for months and years.


Furthermore, they are completely satisfied with the consumer care support for each brand of the above-mentioned Berberine products.

Each product has instructions for use that are written on the bottle.


  1. Berberine HCL: You can take 500 mg once or twice daily or as instructed by your physician.
  2. Sunergetic Berberine: You can take two capsules daily or as instructed by your physician.
  3. Solaray Berberine: You can take one Vegcup daily with your meal, with a glass of water, or as instructed by your physician.
  4. Berberine-500: You can take two capsules daily or as instructed by your physician.
  5. Nuzena Berberine+: You can take 2 capsules a day. The best time to take them is before your meals or as instructed by your physician.
  • Prescription 


You don’t need a prescription to buy the Berberine supplement. You can get any of these pills over the counter or order them online.


Consult with your PCP or a healthcare worker before taking any Berberine supplements. And also, make sure you discuss your current and past medical history with your current PCP.

FAQs On Berberine

If you are pregnant, it is mostly unsafe to use Berberine by mouth or in any other form. According to some studies, the Berberine can cross the placenta, and it might cause some harm to the fetus. In addition, the results have shown that, most likely, a type of brain damage called Kernicterus can develop in newborn babies exposed to Berberine.


If you are breastfeeding, it is unsafe to take Berberine since it can be transferred to the infant, and it might cause some harm as the above-mentioned brain damage.


It is unsafe for newborns or infants since it can cause brain damage. And newborns who have a health condition called Jaundice.


Jaundice is a severe condition that can make the skin, whites of the eyes, and mucous membranes turn yellow because of high levels of bilirubin. Also, if you have this condition and start taking the product, it might lead to hepatitis and tumors.

If you want to see any results, take the Berberine pills around 3 or 4 weeks before noticing any changes.


According to customer reviews, it usually takes three weeks for any positive effect or changes in cholesterol levels, weight gain or reduce blood sugar levels to be noticed. Moreover, it depends on your type of health condition and your age and current health.

According to the studies, there are no severe side effects if you use too much Berberine. This berberine supplement can only help you regulate your blood sugar, hormone levels, and possible heart diseases. It can also treat some metabolic problems, including diabetes and obesity. Overall you can only expect great results, and there is no risk of taking too much Berberine.

You should follow the instructions written on the package. In addition, all reviewed products have information and instructions on how and when to take them.


When taking Berberine capsules, it is not recommended that you take the two or three capsules with a single meal since it won’t be effective and you won’t see any results. And another disadvantage of taking more than one pill at the same time is that it can cause some Gastro problems, such as bloating.


Before using any of the Berberine pills, make sure you contact your PCP.

PCOS is a condition that occurs when a female has a high level of male hormones. The syndrome causes hormonal and also metabolic imbalances. This syndrome usually leads to infertility and even more severe health conditions like high cholesterol, high blood pressure, and getting overweight.


Doctors usually recommend women who have PCOS take the Berberine supplement since it has similar effects as some other prescribed pharmaceutical drugs used to treat PCOS. Additionally, according to some studies, Berberine supplements can be a good treatment for PCOS!

Since Berberine can make some changes in the molecular cells, it has been proven that it can help fight cancer. This is one of the best benefits of Berberine pills.


According to the research done in cancer cell laboratories, it has been proven that Berberine can help with ovarian cancer, prostate cancer, colorectal cancer, lung cancer, liver cancer, and cervical cancer.

Another study shows that Berberine pills can help treat cancer by interfering with its progress and its cycle. As well it plays a role in killing cancer cells.


Keep in mind that this research is only done at special cancer cell laboratories, and they are not done on actual people who are diagnosed with cancer.

Metformin is a blood glucose-lowering agent, and it is beneficial for patients who have impaired glucose regulation.


According to many studies, it is proven that Berberine supplements are much better than Metformin medication since it is an all-natural remedy and has more benefits than taking Metformin medication.


The Berberine supplements work better since they are faster AMPK activators, which means they can draw glucose and blood lipids into a cell. That allows them to be used as energy.

Pure Berberine HCL is the most potent form of Berberine. People bank on this to aid them with weight loss, insulin resistance, lower blood sugar levels, and an overall improvement in the immune system.


Most berberine supplements work differently and you should always check your berberine supplements label to determine whether taking berberine supplements is your cup of tea or not.

Conclusion: What Is The Best Quality Berberine On The Market?

In conclusion, all of the Berberine supplements that we reviewed, Berberine HCL, Synergetic Berberine, Solaray, Berberine-500, and Berberine Pure +, are all-natural remedies that can help you in many ways with your health.


Overall, Berberine Products can help you with high blood pressure, overall wellness, arthritis, and cardiovascular health and helps cancer patients and women with Polycystic ovary syndrome or metabolic syndrome.


We hope that this article provides you with the best information you can get out there on the web regarding the Berberine supplements. We have done the research, and we hope that we can help you get the motivation today to buy some of the reviewed Berberine supplements that can provide you with great results and help you in the best ways possible.


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Juhi Dutta

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