What Is CBDv? Learn About This Cannabidivarin Cannabinoid [Benefits & More]


It is known that cannabis plants have around 120 cannabinoids that provide many benefits for one’s body, mind, and overall health. As cannabis-derived products are becoming legal in many states, their popularity is constantly rising, and as a result, cannabis research is growing as well. If you have been using such products, you have probably heard about CBD and THC, but CBDv has been gaining a lot of attention in recent years.

This cannabinoid was identified even in the late 1970s, but only recently has it been researched. This is because cannabis products were illegal in many states, which refrained many studies on this new cannabinoid.

However, nowadays, some studies show the effects of this cannabinoid for treating different conditions and helping people who are living with them to have better life quality. If this is a topic that interests you, you are probably wondering – what is CBDv? In that case, keep reading to find out more about the effects that cannabinoids offer.

What Is CBDv?

CBDv flower is a non-intoxicating compound that won’t give you the euphoric high that is often associated with high THC cannabis. It has a similar molecule structure to CBD flower buds. They both have 30 stereoisomers and 7 double bond isomers, and the only difference is that in the CBDv cannabinoid, there is a propyl chain.

However, opposed to CBD, CBDv is found in a much smaller concentration in the cannabis plant, so its usage is more expensive when used for medical purposes. If you are looking for CBDv rich strains, you should look for Indica Landrace strains that are pure without any modifications, but such cannabinoids can also be found in some Sativa strains.

When it comes to dosing CBDv, the correct dosage depends on the person’s age, health, body tolerance, and other vital factors. Even though this cannabinoid is natural, knowing the right dosage is significant.

The researchers are studying CBDv, and they are researching the medical benefits from this cannabinoid; and as a result, there are several studies about the potential conditions that it could treat.

Extracting CBDv

When it comes to extracting CBDv, multiple methods are used. As we have mentioned, this cannabinoid is not found in high amounts in the plant, so scientists often use cellular agriculture, which is a form of biotechnology in food production.

By doing so, they expect to get the highest amount of CBDv, which will then be used for medical purposes. Since the studies for CBDv have started only recently, there are not many such products on the market, but we believe that it is only a matter of time before new CBDv hits the market.

How Does CBDv Work?

If you are wondering what CBDv is, you must also wonder how exactly it works. CBDv doesn’t only have a similar structure to CBD, but the both also function similarly through two significant systems known as the Endocannabinoid system and TRP Ion Channels. The ECS is connected with all the organs in the body, and it gets back the message to the neurons that transfer the message from the organs to the brain.

If the ECS is not working correctly, a lot of uncomfortable symptoms such as anxiety, migraines, insomnia, menstrual pain, and others can occur. This cannabinoid doesn’t directly stimulate the endocannabinoid system but increases and decreases the sensitivity of the receptors.

  • Ion Channels

Ion Channels work as sensors in the body and alert the nervous system if there are chemicals and extremely hot and cold temperatures. Such channels are also activated when you are eating spicy food.

CBDv, together with CBD, is said to support certain TRP channels, and for that reason, it has a better effect on treating migraines, neuropathic pain, forms of epilepsy, etc. It is also said that the natural compound has a much higher impact on TRP channels than most of the other cannabinoids found in the hemp plant.

What Are Varin Cannabinoids?

Varin Cannabinoids is a name for cannabinoids known as THCv, CBDv, CBDGv, DCBCv, and others. All of these cannabinoids are considered a subfamily of cannabinoids that have three carbons. The well-known cannabinoids such as CBD and THC contain five carbons, but there are also some other groups that have only one carbon on their alkyl side chains.THC is a popular cannabionoid and the market is loaded with different kinds of THC products incuding THC cartridges, vapes and cigarettes. 

The number of carbons is very significant as it determines which receptors the cannabinoids will bind with and what kind of effects they will provide. If the chain is longer, the effects will be more intense.

CBDv vs CBD: What’s The Difference?

Aside from the African landrace strains, such content can be found in other cannabis strains known as Medical Mass, Dance World, Euphoria, Royal Medic, and others. If you would like to purchase such products, you will not find them easily as there are only several companies that sell such products.

However, they can be found in places where THCv content is found, which is also much more popular due to its psychoactive properties that are not present in the CBDv cannabinoid.

When it comes to the difference between CBDv and CBD, they are both very similar as they provide similar benefits and both have therapeutic properties. Still, cannabidivarin is more suitable for treating neurological disorders and epilepsy activity, while CBD is often used for insomnia, relieving daily stress, reducing symptoms of anxiety, and other similar effects.

What Is CBDv Used For?

The usage of CBDv is the same as when you are using CBD products including CBD capsules, gummies and vapes. However, you can use it by adding it to oils, tinctures, and edibles, or you can even use it in a vape cartridge through the oil or the extract.

This cannabinoid is researched for its benefits in the medical field, but it also contains less than 0.3% THC, meaning that it is legal to purchase and use according to the 2018 Farm Bill. As it is the case with CBD and THC products, CBDv products also have potency, so even though the product is natural, you have to be careful about the right dosage for you.

It is also safe to use as long as you purchase it from a reliable company or seller. However, if you are planning on using CBDv products for medical purposes, then we suggest contacting a medical professional, especially if you are using other medications as well.

No matter what kind of cannabinoids you are using, you need to make sure that you know the right dosage, check the ingredients of a product, and check the seller’s reputation. Recent studies have shown that CBDv has the potential of treating several conditions, so in the continuation, let’s look at the medical effects this compound provides.

Potential Medical Effects Of CBDv & More

As we have mentioned, CBD and CBDv have similar chemical structures with the exception of the propyl chain found in CBDv, but both of them have shown anticonvulsant activity during the studies. It is known that THC provides effects by binding with the CB1 and CB2 receptors in order to give a pleasant buzz that the users seek. However, that is not the case with CBDv, which has an effect on the capsaicin receptor TRPV1.

For that reason, CBDv has anti-epileptic properties, and it is often used in the medical field for treating seizures. Also, this cannabinoid activates the TRPA1 and TRPV2 ion channels that then cause neuronal hyperexcitability reduction and, with that, reduces epileptic activity. Additionally, CBDv is found to provide almost the same benefits as CBD, such as providing calmness and muscle recovery, relieving chronic pain, lessening stress and anxiety, improving sleep quality, and others.

Still, CBDv is more suitable for migraines, seizures, neuropathic pain, and other similar conditions. Let’s have a closer look at some of the studies that were implemented and what has been found so far when it comes to CBDv effects.

Big Pharma studies On CBDv

In recent years, CBDv has gained a lot of attention, so there have been a lot of studies from researchers that were implemented in order to find the medical potential of this cannabinoid. One of the studies was conducted by GW Pharmaceuticals, which wanted to develop this cannabinoid and called it ‘GWP42006’. GW Pharmaceuticals was hoping that this cannabinoid will be effective for epileptic seizures, so they have sent this compound for clinical trials.

Even though their study in 2018 showed that CVDv didn’t meet their primary expectations, they still wanted to continue the study and also extend their research for Rett syndrome, autism, and other conditions. Still, their research showed that CBDv has an effect on the capsaicin receptors that are responsible for the progression of several types of epilepsy.

A study conducted by the European Medicine Agency in 2017 gave CBDv the green light to  be used for Rett syndrome and then for treatment of Fragile X in 2018. Finally, in 2020, FDA also gave CBDv the so-called ‘orphan designation’ for both of these syndromes, and this cannabinoid is continuously studied for ASD by Sanobiotec.

  • CBDv Effects On Childhood Intractable Epilepsy

Childhood intractable epilepsy is also a subject for study, as researchers want to discover the effect of this cannabinoid found in the hemp plant on people who have communication and function difficulties. Thankfully for GW Pharmaceuticals, who opened the door for studies on this newly appeared cannabinoid, there has been compelling evidence that CBDv can reduce chemically-induced seizures, but this study was performed on animals. Now this company is focused on researching the impact of cannabidivarin on autism spectrum disorder.

  • CBDv For Anticonvulsant Activity

British Journal has also studied this cannabinoid in December 2012 and examined CBDv as an anticonvulsant on rats and mice. However, this cannabinoid doesn’t impact regular motor functions, which is very significant. In addition, the Albert Einstein College of Medicine was investigating the effects of CBDv on ASD, while in 2013, it was discovered that this natural compound reduces PTZ seizure activity.

There was also a recent study in 2014 that showed that both CBDv and CBD interact with TPRv1. A recent study in 2019 has discovered that this naturally-occurring compound can treat autism-like behavior, but the study was again implemented on mice.

  • CBDv’s Impact On Autism Spectrum Disorder

Since autism is a disorder that doesn’t have a cure, the treatments are intended to ease the symptoms and support a better quality of life. With that being said, CBDv has been discovered to be effective in alleviating such symptoms and reducing acute anxiety by interacting with the neurotransmitters in the brain and glutamate. Furthermore, people who have autism have lower anandamide levels in the brain, so this cannabinoid is thought to regulate such levels as well.

  • CBDv Effects For Duchenne Muscular Dystrophy & Rett Syndrome

DMD is a condition that causes skeletal and muscle damage and inflammation, so the researchers wanted to find if CBDv has an effect for treatment. Therefore, a study performed on mice published in the British Journal of Pharmacology of 2019 showed that the researchers found that this cannabinoid not only reduces inflammation but also enhances muscle function, which was a significant discovery.

The National Research Council in Italy has also published a study on the CBDv and CBD effects for Duchenne Muscular Dystrophy. The study discovered that both cannabinoids can restore the function of impaired muscle stem cells but only in higher doses. Given all of these points, it can be seen that CBDv, as well as CBD, can be effective for several types of muscular dystrophy.

  • CNDv Effects On Rett Syndrome

Rett Syndrome is a genetic condition that has no cure, so the only possible treatment is reducing the symptoms and improving life quality as much as possible. For that purpose, a study published in the Journal of Psychopharmacology discovered that this compound is able to restore memory defects in mice that have the same genetic defects as humans who are dealing with symptoms of Rett syndrome.

Furthermore, a published study in Acta Physiologia showed that CBDv can decrease gastrointestinal inflammation that is often a cause of other diseases. These studies are often performed on animals, specifically mice. They have discovered that CBDv can improve overall health, improve motor coordination, normalize excess brain weight and also improve sociability deficits.

  • CBDv’s effects As An Anti-Nausea Agent

The studies performed on animals were also intended to explore the effects of CBDv on preventing toxin-induced nausea. Given the fact that the nausea response is connected with the endocannabinoid system, when ECS is stimulated, the symptoms of nausea are reduced.

Another important study was published by the British Journal of Pharmacology which discovered that CBDv works as an agonist on CB1 receptors and, by doing so, blocks the nausea response, meaning that this natural cannabinoid is also beneficial for reducing nausea symptoms among providing many other medical benefits.

What The Future Holds For CBDv?

As shown above, there are many studies that have explored the benefits of the CBDv when it comes to treating severe health conditions. However, even though there is a lack of studies on this novelty compound so far, there are still studies that have yet to show the effects of this naturally occurring compound. So far, it is known that CBDv is helpful for epilepsy activity, ASD, and DMD.

Still, there are still clinical studies that will show the effects of this cannabinoid on CBDV vs. Placebo on children with ASD, Adults up to 30 years old with PWS, and also for alopecia treatment, which was not mentioned before. This novel formulation is yet to become a new favorite on the market due to the benefits it provides for many people who are living with different conditions.

  • Additional Information

Additionally, a company that develops cannabinoid medicine has announced that they have completed a pre-clinical trial of a medicine that contains a combination of CBDv and CBGA for treating gastrointestinal cancer.

Also, it states that since these cannabinoids don’t have any psychoactive properties, the patients will be able to use them in higher dosages if needed and as recommended by the healthcare professionals without worrying about getting them. However, there are yet to be studies on this novel cannabinoid and the potential it has on treating severe disorders and health conditions.

Conclusion – What Is CBDv?

In the final analysis, we can state that CBDv is a naturally-occurring compound found in the hemp plant that has therapeutic properties and provides essential medical benefits. Since weed was illegal in many states and a negative stigma surrounds it, CBDv was not studied even though it was discovered a long time ago.

However, since cannabis and hemp-derived products became legal and more and more popular, a lot of scientists have wanted to investigate the effects of this naturally-occurring cannabinoid for treating severe conditions. Given all these points, this cannabinoid is here to stay, so it is expected that there will be a lot of studies performed and CBDv strains developed, as it is the case with the other compounds such as CBD and THC.

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