Nucific Bio X4 Review: Is It The Best Supplement For Weight Loss?

Nikhil Goswami
mid section view of a woman measuring her waist

Maintaining a healthy diet and exercising are everyone’s goals, but most people can only do so much with little time. For most people, healthy living is a luxury. Luckily, supplements exist to make healthy living a possibility for everyone. The dietary supplements market is filled with numerous products from different brands, with some promising quick, instant results. Weight loss supplements are meant to make your weight loss journey a lot less complicated.

Do not compromise your digestion or immunity when choosing a weight loss supplement. You may be tempted to go for crash diets and laxatives, which are only quick fixes with rebound effects. You need supplements that can help you lose weight and help you achieve a healthy life overall. One such supplement is the Nucific Bio X4. Our detailed review looks at this weight management probiotic’s ingredients, benefits, and risks. Is it worth it? Or is it a scam? Read on to find out.

Brand Overview

The biggest challenge for most people struggling with weight loss is reconciling their appetites for fatty and sweet foods with the energy loss and metabolic shifts that result from diet modifications. Nucific created Bio X4 to help users lose weight by suppressing their appetites and increasing the fat-burning metabolism rate.

Based in California, Nucific is the company behind the brand Bio X4. The company is relatively new to the market but provides enough information about its products to the public. The firm’s primary goal is to offer its customers scientifically developed natural products to help them achieve a good life and body.

The company is registered with the Better Business Bureau and has several positive and a few negative reviews. In all fairness, the negative reviews are about ordering and overcharging, and they all seem to have been resolved. Furthermore, the founder, Dr. Amy Lee, is a certified physician with vast knowledge about obesity medicine.

Besides Bio X4, Nucific offers a wide range of supplements, including; Probiotic Complex, Deep Cell Activator, Nucific Slimming Chocolates, Dr. Amy’s Bone Broth, and Antarctic Krill Oil.

Bio X4 is a probiotic-based natural weight loss remedy. The supplement helps improve digestion and promotes a healthy metabolism, and its organic components are a highly effective craving-control and weight-management blend. The blend consists of probiotics, digestive enzymes, Caralluma Fimbriata extract, and green tea extracts. The probiotics are responsible for optimizing digestion and restoring your gut microflora.

According to Nucific’s official website, Bio X4’s ingredients can boost the nutrients in your body as well as improve your sleep if you have any sleep disorders. Further, Nucific claims all the ingredients in the supplement are gluten-free.


  • Improves digestion and regulates the bowel
  • Boosts energy levels
  • Helps prevent opportunistic illnesses
  • Reputable manufacturer
  • Evidence-based organic ingredients
  • Gluten, lactose, and allergen-free ingredients
  • Eco-friendly packaging makes it ideal
  • Highly informative company website
  • 90-day money-back guarantee


  • Inadequate convincing research on weight loss benefits
  • Only available online

Who Should Use Nucific Bio X4?

Bio X4 can help anyone looking to lose weight in a healthy way without using harmful prescription drugs or hard-to-follow diets. You should be able to see some positive change after 60 days of consistent use. Nucific advises users to combine the supplement with lots of exercise and healthy balanced meals for top effectiveness.

Anyone who wants to enhance their gut health can also use Bio X4. The probiotics and the enzymes in the supplement can help digest food more efficiently. Moreover, it contains green tea, which can help speed up your system.


Bio X4 features four natural elements that aid in weight loss and support gut health;

  • Weight management blend: EGCG green tea extract
  • Craving control blend: Caralluma fimbriata
  • Probiotic blend: Lactobacillus and Bifidobacterium
  • Digestive enzyme blend: amylase, bromelain, and lipase

The Caralluma Fimbriata and the EGCG are the most crucial weight-loss elements. The other two are probiotic elements which also have great benefits.

  • Weight Management Blend

The main ingredient in the weight management blend is green tea extract (GTE). The green tea extract has about 50% of EGCG, a plant compound found in green tea leaves. EGCG is responsible for all the health benefits of green tea, including burning body fat and boosting metabolism.

The research around EGCG is quite mixed. According to a 2013 research review, there is no clear information about EGCG’s ability to improve fat metabolism as a few studies have concluded that it can, and others have not.

In some studies reviewed in the research, users taking 270 mg of EGCG per day recorded positive results regarding the compound’s fat-burning potential. If you are on a 50 mg dose of EGCG per Nucific Bio X4 capsule, you would have to take at least six capsules per day to maximize the fat-burning potential of the supplement. Fortunately, Nucific Bio X4 employs some other blends to improve fat burning.

  • Craving Control Blend

The craving control blend in Bio X4 is known as Slimaluma. This ingredient is an extract of a certain type of cactus native to India. Some theories claim that CFE reduces appetite, but a 2015 randomized study on CFE shows no benefit in taking it.

In contrast, a more recent 4-month study shows more of an effect. The subjects who used CFE consumed 245 fewer calories every day in the study, and they also lost weight and noticed a reduction in their weight. While the results sound promising, the subjects only lost one pound on average and about an inch off their waistlines, which is not so significant in four months.

Moreover, the ideal dose of CFE is still unclear and under research.

  • Probiotic Blend

Essentially, probiotics are live microorganisms. They are bacteria beneficial to the gut and are associated with many other health benefits. Mainstream medicine uses probiotics to manage serious health issues like irritable bowel syndrome.

A healthy balance of gut bacteria dramatically influences the human immune system as the gut is associated with many body parts. Your gut health affects your weight management, brain health, overall mood, and the digestive tract. Moreover, probiotics play a crucial role in extracting nutrients and energy from food during digestion.

You can get probiotics from fermented foods like yogurt, but they do not guarantee an adequate amount of healthy bacteria for your gut. Bio X4 has approximately four billion colony-forming units (CFUs) in every capsule. The number indicates the amount of bacteria in the supplement and its potency.

Bio X4’s probiotic blend consists of two types of gut bacteria; Lactobacillus and Bifidobacterium. Both bacteria have different strains.

  • Lactobacillus

Lactobacillus is a bacteria that supports proper digestion and overall health. The Lactobacillus strain consists of three different strains; L. acidophilus, L. rhamnosus, and L. Plantarum.

The three Lactobacillus strains are the most widely studied probiotic strains. According to WebMD, Lactobacillus is good for diarrhea and general digestion problems. The human body naturally contains many Lactobacillus bacteria, but you can consume it from fermented foods like yogurt or dietary supplements.

According to a 2018 research review, L. rhamnosus can improve digestive symptoms like constipation and diarrhea. In addition, another 2020 research review indicates that L. acidophilus can help manage acute or chronic diarrhea and antibiotic-induced diarrhea. As for L. plantarum, there is evidence from an animal study that it can support a healthy digestive tract and microbiome.

Although there is enough research on the benefits of this bacteria to digestive health, there isn’t enough evidence showing its ability to manage food cravings and promote weight loss.

  • Bifidobacterium

Bifidobacterium is one of the main types of bacteria lining the gastrointestinal tract. Bio X4 contains two major strains of Bifidobacterium: B. animalis and B. lactis. According to a 2010 study, B. lactis can manage gastrointestinal symptoms like constipation. B. animalis, on the other hand, was evidenced to have a protective effect against diarrhea in a 2014 research review.

Although the extensive research on Bifidobacterium looks promising, there is no clear information about the ideal CFU amount that can produce the benefits. What’s more, most of the studies available only show a connection between Bifidobacterium and digestive problems. The direct effects of taking the probiotic in supplement form are still unclear.

  • Digestive Enzyme Blend

The Bio X4 digestive enzyme blend consists of three digestive enzymes; Lipase, amylase, and bromelain. Amylase breaks down carbs, while lipase breaks down fats. Both enzymes are crucial and are naturally present in the human digestive system alongside other digestive enzymes.

You can get amylase and lipase from foods like mangoes, papayas, and avocados. You don’t need to take amylase or lipase in supplement form unless you have a deficiency. When both enzymes are insufficient in the body, you may suffer gastrointestinal symptoms like bloating and diarrhea. In such a case, you may be prescribed enzyme medications that are coated in a special material so that they can survive the harsh acidic conditions of the stomach.

It is unclear whether the enzymes in Nucific Bio X4 have any special coating for surviving the acidic stomach. Therefore, the enzyme’s effectiveness in aiding digestion is unclear.

Bromelain supports protein digestion and has multiple health benefits, and studies show that it can help manage diarrhea and respiratory conditions. According to a 2012 research review, bromelain has the potential to reduce diarrhea caused by infections like Escherichia coli in animals. No human trials on bromelain’s role in supporting digestion exist.

In a nutshell, it is not clear if the digestive enzyme blend can benefit you unless you are diagnosed with a digestive enzyme deficiency.

How Does Nucific Bio X4 Work?

Nucific Bio X4 is a dietary supplement that provides a four-way defensive strategy against a big appetite, indigestion, and metabolism. According to the company’s website, you need to use Bio X4 for some time before you observe noticeable results. You may not achieve the best results if you skip a day or two. What’s more, you cannot make up for days you miss with an extra dose. So, how does the unique blend of ingredients work to help you lose weight?

The probiotic blend in Bio X4 might help restore the good bacteria in your body to give you a healthy bacteria balance. It may also help offset irritable bowel syndrome and any allergic reactions.

The green tea extract may increase your energy and metabolism levels, thus helping you lose weight. Moreover, the Caralluma Fimbriata curbs your food cravings and reduces your appetite.

The company recommends leading a healthy lifestyle by eating healthy and exercising to get the best weight loss results when using this product. Also, you are advised to keep off sweets when using the product.

Benefits of Nucific Bio X4

Besides weight loss, there are myriad other benefits associated with Bio X4. Some of the benefits include:

  • Boosting the immune system
  • Maintaining a high body energy level
  • Improving digestion and general body health

Moreover, Bio X4 is eco-friendly as the company uses eco-friendly packaging. Nucific also claims the product’s ingredients are lactose, gluten, and allergen-free. Another benefit of Bio X4 is that its manufacturer’s website has enough information about the product.

Do note that the results of consuming Bio X4 vary from person to person. One may lose weight in two or three weeks of taking the supplement, while you may be forced to go a couple of months before seeing significant results. Thus, do not be hasty to disregard the supplement just after a few days if you do not see any changes.

Side Effects

According to Nucific, some users may have an allergic reaction to some of the supplement’s ingredients. So, you need to go through the entire product label and descriptions to see if anything in it could put your health at risk. Further, pregnant women and nursing mothers are advised to seek medical advice from a doctor before using the supplement.

Here are some side effects related to the different blends contained in Nucific Bio X4:

  • Probiotics

Although probiotics are promoted as safe and healthy for everyone, some may show side effects like flatulence and bloating. Also, if you have a pre-existing medical condition like short bowel syndrome or a weak immune system, seek medical advice before using probiotics. Probiotics may be harmful to you and cause worse complications like an infection.

Another potential side effect of probiotics in Nucific Bio X4 is caused by biogenic amines, which are naturally found in some foods rich in probiotics, like kimchi and yogurt. Biogenic amines result from protein fermentation, including histamine, tryptamine, tyramine, and phenylethylamine. Amines can create excitement in the CNS, resulting in an increase or decrease in blood flow.

Certain strains of bacteria can cause histamine production in the digestive tract. If you are intolerant to histamine, you may have a problem dealing with the condition. So, it is advisable to keep off a high histamine diet and supplements with high histamine bacterial ingredients like some strains of Lactobacillus.

  • Caralluma Fimbriata

Caralluma Fimbriata appears to be the best-tolerated ingredient of Bio X4. Generally, it is safe for consumption and will not lead to severe complications. Nonetheless, you may experience minor side effects like constipation, nausea, bloating, and other forms of gastrointestinal problems.

  • EGCG

EGCG is just as well-tolerated by the body as Caralluma Fimbriata. It is safe for consumption by healthy people and has no dire side effects. However, EGCG is not 100% risk-free, especially if consumed in supplements. Studies show that dizziness, low blood sugar, anemia, and liver and kidney problems are possible side effects of EGCG.

According to experts, the side effects may occur because of contaminants in the supplements. Further, EGCG can prevent the proper absorption of some prescription medicines. This is why it is essential to seek medical advice before using any dietary supplement, especially if you are on medication for any underlying health issues.

Research shows that consuming EGCG in doses of 800 mg per day or more can cause liver damage. While it sounds concerning, the EGCG in Bio X4 is much lower. A 2018 review found out that consuming up to 338 mg of EGCG in capsule form is safe. Considering the amount of EGCG in Bio X4, you’d be consuming 300 mg per day if you are on a dosage of six capsules.

Who Should Refrain From Using Nucific Bio X4

Nucific insists that Bio X4 is not for everyone. While it has many benefits, some people should better avoid the supplement. The following groups of people should not use Nucific Bio X4:

  1. Pregnant or Lactating Mothers

If you are pregnant or breastfeeding, you must seek advice from your doctor before using any supplement. There isn’t enough information about the ingredients in Bio X4 regarding their safety in childbirth. Even when breastfeeding, the supplement’s contents may affect the child’s development. Since they still have fragile immune systems, even small amounts can have dire consequences.

  1. Children Below the Age of 18 Years

Weight loss supplements are not recommended for children. Only adults who want to lose weight and have a compromised digestive system should take any weight loss or probiotic supplements. Contact your doctor for guidance if you think you must use it, and you are below 18 years.

  1. People With Underlying Health Conditions

People with preexisting medical conditions or weak immune systems are advised to avoid using any weight loss or probiotics supplements. Some of the ingredients in Bio X4 may interfere with the absorption of medicines or worsen the effects of certain diseases. Therefore, do not use such products until you have consulted your doctor.

  1. People With Unrealistic Expectations

Unlike most weight loss supplements, Nucific does not promise instant effects for weight loss with Bio X4. The best way to get the best weight loss results is to take the supplement recommended by the manufacturer and combine it with a healthy lifestyle. If you want instant weight loss, this supplement will not work for you.

Dosage and Tips to Start

Nucific recommends taking three capsules of Bio X4 every day. You can take one pill before every meal if you take breakfast, lunch, and supper. You can take more than three pills if you want but do not exceed six to avoid complications.

Taking a capsule before your meal with plain water will help improve your digestion. Before taking Bio X4, keep in mind that the supplement does not cure or treat any diseases. Moreover, many factors influence its effectiveness. Consult a doctor if you experience any weight gain or persistent digestive problems.

Where to Buy Nucific Bio X4 and Guarantees

The best place to buy Bio X4 is from the Nucific website. You may get the supplement from Amazon at a cheaper price. However, since the sellers are third parties, you cannot be too sure that whatever is on the label is inside the bottle.

You can either make a one-time purchase when you visit the website or subscribe to the website for a monthly 10% discount. Furthermore, when you buy it from Nucific’s website, you get a 90-day money-back guarantee. The guarantee allows you to return the supplements if you are not happy with the results. As long as you are within the given time, you will get a refund.

Nucific Bio X4 Alternative – PhenQ

The supplement market is filled with products with similar weight management and digestive health claims as Nucific Bio X4. The popular PhenQ is an excellent example. The expected results of PhenQ are comparable, and you can apply them similarly.

PhenQ’s biggest selling point is that its ingredients are 100% vegan. Its primary ingredient, A-Lacys Reset, is a proprietary formula with different ingredients that can accelerate your metabolism and increase thermogenesis. A-Lacys Reset is what provides Phen Q with its impressive fat-burning power.

Like most weight loss supplements, PhenQ comes in the form of tablets you must take daily. The standard dose is two daily tablets, and you can take them with the first two meals of the day: breakfast and lunch. You can refer to PhenQ Reviews.

Although PhenQ claims to have developed A-Lacys Reset with cutting-edge science and research, they don’t provide clinical evidence to prove the weight loss benefits of the formula. However, the company provides links to research studies that support the weight loss benefits of the supplement’s other ingredients.

Brand Overview

PhenQ is a popular weight loss pill manufactured by Wolfson Brands in the United Kingdom. Wolfson Brands manufactures health and wellness supplements and has been in the industry for over 15 years. PhenQ is one of its new weight loss products, but it has grown in popularity quickly. The company markets the supplement as five powerful supplements in one. It has a formula that will support your weight loss journey by helping you burn fat and consume fewer calories. It may also boost your mood and energy levels.

PhenQ focuses on weight loss by suppressing appetite and preventing fat production. It also boosts energy levels so that you can spend more time on a workout. The company, Wolfson Berg, has taken a different approach to help you lose weight. The supplement doesn’t only work by reducing excess fat in the body but also facilitates other fat-burning processes such as keeping you fuller for longer, curbing unnecessary food cravings, and keeping you energized even when you have consumed a few calories.

The company manufactures its supplements in GMP-certified and FDA-approved facilities in the U.S. and the U.K. In addition, all of its products are available with free shipping worldwide. You can only purchase PhenQ from the official website of the brand. Apart from PhenQ, Wolfson uses powerful and scientific formulas in all of its products that bring amazing results in terms of health and wellness.


The PhenQ supplement consists of six clinically approved ingredients. It is an all-natural supplement and is a perfect choice for those who are looking to shed weight in a natural way. The ingredients in this supplement include;

  • Capsimax powder: Like A-Lacys Reset, this has solid thermogenic powers.
  • Calcium carbonate: This offers the daily recommended value for calcium. Research shows that calcium deficiencies are associated with higher body weight; therefore, increasing calcium intake may enhance weight loss.
  • Chromium picolinate: This contains the recommended value for chromium, which is an essential mineral that helps reduce sugar and carb cravings.
  • L-carnitine fumarate: This helps the body burn fat into usable energy.
  • Caffeine: This provides energy and supports a faster metabolism by increasing thermogenesis.

Unlike Nucific Bio X4, PhenQ promises quick results. It also has a more precise dosage as you only need to take one pill with your food twice a day. PhenQ’s shipping and return policy also looks more attractive with free worldwide shipping and multi-buy discounts. The only downside is that they offer a 60-day money guarantee, whereas Nucific provides a 90-day money-back guarantee.

Side Effects

PhenQ also has a few drawbacks, like every other supplement out there. According to the website, the supplement has no particular side effects. However, the customer reviews on the website state the experiences of users who had minor side effects. Plus, the percentage of users who had slight effects was very low. PhenQ consists of natural ingredients that don’t produce any adverse side effects on most users.

Second, it has caffeine as a primary ingredient, which may cause sleep problems among some users. What’s more, unlike Nucific Bio X4, PhenQ’s ingredient blend has limited scientific support. Also, the supplement is not entirely risk-free, and you may experience some mild side effects like restlessness, dizziness, bloating, headache, nausea, and an upset stomach.

Apart from that, you shouldn’t drink any drinks such as energy drinks that contain caffeine. Moreover, you shouldn’t use PhenQ if you have any medical condition or have medicine to treat an illness. The supplement is also not suitable for people under 18 years of age.

How Much Weight Can I Lose In A Month On PhenQ?

Weight loss supplements have varying effects on people since everyone has a different body and mechanism. Everyone experiences weight loss at a different pace, and you must continue consuming the supplement until you achieve your desired weight loss result. The majority of users may experience a reduction in weight within 30 days. The supplement helps you lose 2 pounds per week, which means that you’ll be able to lose 8 pounds in one month on PhenQ.

However, like with every other supplement, you must consider having a healthy lifestyle to promote weight loss. For instance, you must maintain a healthy and balanced diet and work out regularly. You must maintain a calorie deficit by avoiding junk food and increasing your activity level. PhenQ helps promote weight loss, but that doesn’t mean that you just consume the supplement and become careless with your eating habits. After you have achieved your desired weight, you can stop consuming PhenQ. Plus, you can also stop consuming the supplement if you don’t notice any visible results during the period of 30 to 60 days.

Conclusion: Nucific Bio X4 Review 2022

Nucific is a popular and trusted brand, and Bio X4 is one of their top products with scientific backing. The supplement is safe to consume and has few side effects. Nucific markets Bio X4 as an effective probiotic supplement with a powerful four-way defensive strategy for weight loss. The company claims that all the supplements’ ingredients have great weight loss benefits and can improve the body’s overall wellness.

Furthermore, more studies should be conducted to confirm the effectiveness of Bio X4. Some of the ingredients may help you lose some weight, but it is highly unlikely that it would be a huge amount. According to the studies available, the amount of weight you may lose with Nucific Bio X4 is not significantly different from the results you would get from losing weight without any aid.

On the bright side, the probiotics in this product may help relieve the symptoms of certain infections like diarrhea. However, it does not cure any severe illnesses. Be sure to consult with your doctor before using the supplement, especially if you have any underlying health conditions. To get the most out of Nucific Bio X4, combine it with a healthy lifestyle that combines healthy eating, regular exercise, reduced stress, and excellent sleep quality.

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