Best NMN Supplement 2022: Top 3 Brands Reviewed


Aging is optional if the extensive research on longevity is anything to go by. The rise in research has grown exponentially since the release of Lifespan, a 2019 book by David Sinclair. The book extensively covered NMN, a molecule your body uses to generate (nicotinamide adenine dinucleotide)

So, what exactly is NMN? NMN stands for (nicotinamide mononucleotide) and is a compound derived from niacin, commonly known as Vitamin B3. It synthesizes NAD, which is present in the cells. Low NAD levels adversely affect body functions; unfortunately, this happens as you age. Trace amounts of NMN can be found in natural food sources like raw beef, vegetables, and fruits.

To that end, we have compiled this guide to the best NMN supplements. It contains information that we gathered from various sources to ease your choice. Let’s get to it without further ado.

Our Top Picks For The Best NMN Supplements To Buy In 2022

  1.  Wonderfeel® Youngr™ NMN– Overall Best NMN Supplement, Editors Pick 
  2. Invity NMN– Most Recommended Brand With Fastest Delivery Options
  3. PURE NMN – Best Premium Quality Supplement With Third Party Tested Assurance

#1. Wonderfeel® Youngr™ NMN– Overall Best NMN Supplement, Editors Pick

  Opening this list is Wonderfeel® Youngr™ NMN is a patented solution for healthy aging. These boosters come in NMN capsules derived from vegetable cellulose, making them vegan-safe. In addition, such supplements are free from preservatives. It doesn’t contain dairy, fish, soy, or GMO products, which makes it safe for consumption.

The manufacturers formulate it with antioxidants to slow the aging process at the cellular level. Some of the natural ingredients used to make these NMN capsules include ergothioneine, which is dubbed the longevity vitamin, and resveratrol, which acts as a sirtuin activator during the manufacturing formula. In addition, the manufacturer also uses vitamin D3, which partly plays in immune function, but aging affects it.

Wonderfeel® Youngr™ NMN is among the best NMN brands because of Andrew Salzman, MD of Harvard University. This physician, scientist, and professor doubles up as a drug inventor with over 50 patents. He is also a pioneer in cellular health, including mitochondrial. It’s safe to say that NMN capsules from Wonderfeel® Youngr™ NMN are safe to use in slowing down aging. But why should you buy from this brand?


Dose Backed By The Clinical Study: This brand has backed its NMN dose with the latest human clinical study, making it suitable if you aren’t sure what to take. The company has published the findings through partner authors. It will help to review the reports and establish the ideal dose you should take. Note that professional medical advice is also essential before you start supplementing NMN.

Efficacy: The bioscientist formulating this pharmaceutical-grade NMN anti-aging supplement ensures it’s effective. Our research findings indicate that users have reported positive results from supplementing NAD booster manufactured by Wonderfeel® Youngr™ NMN. It’s with no doubt that it deserves to be among the best NMN supplements.

Safety: Wonderfeel® Youngr™ NMN uses FDA-approved facilities to make the NMN capsules, making them safe for human consumption. Despite the lack of regulatory authority, this brand goes a long way to ensure that its NMN supplement is safe.

Third-Party Lab Test: Such supplements are adulterated with impurities. This brand ensures that its products are in the purest form by checking every batch in third-party laboratories. While at it, the technicians compare the products with other supplements in the market to ensure they are of the best quality.

Favorable Policies: This brand also has favorable policies, which should drive you to purchase from them. For instance, it has a limited-time price for new users, which you will enjoy, provided that your subscription is active. In addition, you will get free monthly shipping. And you can cancel the subscription at any time, no questions asked.


  • Natural ingredients
  • Vegan-friendly
  • Effective boosters
  • Safe products
  • Third-party lab test


  • they do not offer coupons and discounts 

=> Click here to visit the official website of Wonderfeel Youngr

#2. Invity NMN– Most Recommended Brand With Fastest Delivery Options

Invity NMN is another brand that manufactures liposomal NAD boosters worthy of making it to this list. This brand is rooted in science and started this journey of producing NMN with a mission of redefining lifespan through scientific exploration from nutrition to phytochemistry. The founder’s main goal was to make longevity achievable.

This company produces premium NAD booster that can help you pause aging. The NMN capsules contain other active ingredients, such as levagen, to help muscle recovery and enhance sleep quality. NMN dose from Invity also contains fucoidan, a potent antioxidant that promotes metabolism in your body.

Such supplements from Invity are free from cruelty and are scientifically formulated. In addition, the products come in clear labels which indicate the ingredients. Regarding transparency, this NMN brand tests the batches of each supplement to ensure purity and safety standards, then post the certificates of analysis to enable review. It would be best if you consider Invity when shopping for such supplements. Below are the reasons why.


Vertical Integration: Unlike other supplements, this brand uses vertical integration to conduct its research. This feature allows it to control the quality of its products, from natural farm ingredients to capsules. Its team of qualified contributing scientists sees that quality is achieved in every step.

Pure Products: Invity ensures the products are in the purest form since purity affects bioavailability. The brand ensures this by testing the raw materials in accredited labs. In addition, it uses approved facilities for processing these high-quality NMN capsules. This makes the NAD boosters from this company safe for consumption.

Different Types Of Supplements: This brand has different types of such supplements to boost NAD levels. For instance, it has the Ultimate NMN 1200 and NMN+ BIOSIRIN. Besides the supplements, you can find activating cream concentrate and Ultimate Polyphenols. This range allows you to add other products that will give you quick results when you use them with NMN.

Educative: There is a lot of information regarding nicotinamide mononucleotide supplements; some are misleading. Invity ensures that its users are well informed by dedicating a section on its website for learning. You can get details on how to dose NMN, among other information, from the section. It will help if you review it as you shop to understand how such supplements work.

Secure: Invity acknowledges the risk of transacting online and uses industry-standard encryption to protect your information. The details you use to sign up on the platform are safe. In addition, it has a privacy policy that prohibits the brand from sharing your details with third-party entities. Therefore, it’s safe to say that Invity is one of the places to buy such supplements.


  • Transparent
  • Safe products
  • Pure supplements
  • Fast delivery
  • Cutting-edge research
  • Private


  • Confusing to newbies

=> Click here to visit the official website of Invity NMN

#3. PURE NMN – Best Premium Quality Supplement With Third Party Tested Assurance  

is Aeturnum, which produces PURE NMN – Nicotinamide Mononucleotide NMN (Beta, β-NMN). This liposomal NMN is among the best you can find in the supplements market.

Unlike NMN tablets, taking this supplement through sublingual delivery has proven effective. In addition, unlike supplements in pill form, NMN (Beta, β-NMN) is easy to consume without going wrong on the dosage. This is because this brand gives a scoop that you can use to control the dosage.

This brand also uses natural products that are vegan-friendly and non-GMO. Furthermore, the supplements are cruelty-free and don’t contain dairy products. You can take this NMN without the worries of allergic reactions. Regarding policies, Aeturnum ensures quality and a 100% money-back guarantee if you aren’t satisfied.

Aeturnum makes its nicotinamide mononucleotide in FDA-approved facilities, making the end products high-quality. In addition, this brand certifies its products through an accredited third-party laboratory. Below are why you should try this brand when you want to buy such a supplement.


Rigorous Testing: This company goes to great lengths to ensure that the end product is pure. For instance, it rigorously tests its raw materials to ensure they have the necessary nutrients that can help you age healthily. In addition, it periodically carries out human clinical tests to ensure the supplements are effective.

Impeccable Services: Aeturnum has impeccable service that will make your experience pleasant. It has round-the-clock customer service ready to help should the need arise. For instance, you can contact customer service for assistance when placing your order is challenging. Customer support also answers the burning questions you might have.

Disclaimer: This company issue disclaimer enlightens you on the risks of using their supplements. For example, it warns that you should seek advice from a qualified medical professional before using the nicotinamide mononucleotide. And it explicitly states that the products aren’t FDA approved to allow you to make your judgment. You can find this information at the bottom part of its official website.

Fast Shipping: This brand acknowledges that you can urgently need supplements to help you with age-related health conditions. Therefore, it processes its orders within the same working day to ensure that it’s dispatched in time. Furthermore, it uses the fastest delivery to ensure you get your shipment in time and in good condition.

Worldwide Shipping: You can buy this product in several countries other than the USA. Some of the countries include Singapore, Europe, Japan, and Australia. This makes it accessible to other users who want to reap the health benefits of such supplements. However, it will help to inquire if the company delivers to your country before placing your order. Doing so will save you from the disappointment of finding that you can’t receive your order.


  • Transparent
  • Vegan-friendly
  • Pure supplements
  • Comes with a scoop
  • Money-back guarantee
  • Third-party lab tested


  • Not informative

=> Click here to visit the official website of PURE NMN

How We Made This List Of The Best NMN Supplements? 

As we mentioned earlier, the book by David Sinclair raised interest in using suchsupplements to slow the aging process.For that reason, many people consider it as one of the best anti-aging supplement. However, with it came supplement manufacturers, some with questionable characters. Therefore, we had to choose the NMN brands that made it to this list of the best NMN supplements.

We did so by interviewing top industry players and going through research papers. In addition, we also considered several factors that qualified the brands in this list. Below is the detail on how we settled on our top picks.

What We Looked For? 

  • Ingredients: We first considered the manufacturers’ ingredients to make the supplements. In this case, we were particular about the hypoallergenic qualities of the ingredients. The NMN brands in this list use gluten-free ingredients to ensure that their NMN product doesn’t cause allergic reactions. In addition, the ingredients are non-GMO, which makes the anti-aging supplements safe to use.
  • Grade: NMN products of 99% pharmaceutical grade are the best because of the stringent multi-steps processing, ensuring top-notch quality. We considered this factor for an NMN brand to make it to this list. All of them are pharmaceutical-grade NMN.
  • Third-Party Lab Test: Since no oversight authority governs the supplements industry, we ensured that the NMN brands in this list have good manufacturing practices. The practices allow them to produce high-quality nmn supplements. In addition, the brands in this list take such supplement to third-party labs for testing to ascertain the absence of impurities. They also go a step further and post a certificate of analysis to prove purity.
  • Efficacy: We reviewed the available research and test to determine the efficiency of the NMN supplements in this list. Additionally, we interviewed users to determine if a particular NMN works as it promises to make it to this list. The NMN brands we reviewed below proved to be effective in slowing the aging process.
  • Safety: Supplementing NMN comes with many risks, such as the potential to affect pancreatic β-cells, liver, kidney, and cells in plasma. Therefore, we ensured that the brands in this list acknowledge the risk and produce safe NMN supplements. Besides that, we checked if the brands guide users on the correct nmn dose to take and issue legal disclaimer statements as supposed for dietary supplements.
  • Brand Reputation: We also looked into brand reputation when making this list of the best NMN supplements. The brands that made it to this list are reputable, with a proven track record in high-quality NMN supplements and transparency. These NMN brands also warn users to seek professional medical advice before using the NMN.
  • Customer Experience: We considered customer experience when shopping from these brands and using NMN. The positive customer reviews of the brands we have reviewed below paint a good picture. We sampled the reviews to ensure that they aren’t fake, as some unscrupulous brands are fond of publishing. It’s safe to say that the brands below offer the best NMN supplements.

Buying Guide: Factors To Consider When Buying NMN Supplements

You must be careful with the supplements market awash with NMN products. It would be best to consider the following factors as you choose a high-quality NMN supplement. Doing so will give you the best NMN supplement laden with anti-aging benefits.

  • Ingredients

It would be best to consider the ingredients since some anti-aging supplements are made from dangerous ingredients. You should consider if the ingredients are gluten-free, non-GMO, and vegan-friendly. Your anti-aging supplement shouldn’t put you at risk of allergic reaction as you pursue healthy aging. Most nmn brands list the ingredients for identification, which will help if you read them before using them.

  • Efficacy

There is no point in buying ineffective nmn supplements. Therefore, it will help if you thoroughly do a background check to ascertain effectiveness before you buy such supplements. You can find this information in relevant online forums or in the NMN supplement’s review section.  Ensure you review a couple of research papers to ascertain if the NMN product is effective.

  • Safety

Using nicotinamide mononucleotide supplements come with some risks, such as organ failures if overused, for instance. Therefore, it would be best to ensure that the nmn product is safe for consumption. The best way to do so is by buying your NMN supplement manufactured in an FDA-registered facility. In addition, ensure that suchsupplement is from a reputable brand that issues the necessary legal disclaimer for dietary supplements.

  • Third-Party Lab Test

A recent third-party lab test of most NMN supplements found contaminations. Therefore, buying tested and approved NMN products would be best only. The brand you buy from should publish the certificate of analysis so that you can be sure of the third-party lab and purity of the NMN product. The brands here offering the best supplements publish these reports for transparency, which is one of the reasons you should buy your NMN supplement from them.

  • Customer Experience

Lastly, it will help if you also consider the experience of past customers. Doing so will help you buy the best NMN supplement, giving you the health benefits you need. In addition, it will save you a ton from the frustration of buying your nmn supplement from an unreliable vendor. Make a point of going through past customers’ reviews to determine if the brand is reliable and the effects you can expect from such supplementation.

FAQs Regarding NMN Supplements

Is NMN legal?

Yes, NMN is legal in the USA, and the government allows its usage as raw material for manufacturing nutrition supplements. However, note its sold as a nutritional supplement and not a drug approved by the FDA. Therefore, as per the Dietary Supplement Health and Education Act statute, you won’t be breaking any law by taking such supplementation.

At What Age Can You Start taking NAD Boosters?

There is no scientific proof that using such supplements at a young age is dangerous. However, the recommended age to boost NAD is 35 years. If you are younger, it would be best to take 250 mg of NAD booster daily in the morning, mostly before breakfast.

Why Are NMN Supplements Expensive?

The NMN products are expensive because producing pure NMN powder is costly. The innovative manufacturing process entails enzymatic synthesis and goes through six stages for producing NMN molecules. In layman’s language, the process moves from nicotinamide to nicotinamide riboside (NR) and then β-nicotinamide mononucleotide (NMN). This process requires high-tech facilities and rigorous tests afterward. Therefore, the high cost is due to what goes into the production of NMN supplements.

How Do NMN Supplements Work?

NMN supplement works by passing through cell membranes since the NMN molecule is comparatively smaller than NAD.  When you take NMN products, also known as NAD boosters, they increase your body’s NAD levels, which helps improve cellular health and energy metabolism, hence the anti-aging effect. As a result, you will benefit health-wise such as reduced aging effects.

Which form Of NMN Is Best?

NMN products come in sublingual powder, tablets or capsules, and intranasal NMN. The sublingual powder is arguably the best because it’s more bioavailable. It also uses liposome, which enhances absorption in the mouth or prevents breakdown by stomach acid. Other users prefer intranasal NMN. Therefore, it depends on how comfortable you are with the method. Still, sublingual delivery should be your to-go-to option since liposomal NMN is more efficient. Note that whichever the case, it will help if you take the right dose to avoid adverse effects.

What’s The Ideal NMN Dosage?

There is limited data on such supplementation, which makes it challenging to know the ideal dose. Nevertheless, some studies give insight into the dose you should take. For instance, in one mice study, 100 mg/kg of NMN mitigated age-related health conditions.

Based on this finding, it’s best to take 500mg daily if you weigh around 137 pounds. However, start with a low NMN dose and increase with time. And most importantly, seek professional medical advice for proper directives.

How Long Does It Take Before The Effects Of NMN Supplements kick In?

Effects of NMN kick in immediately if you use sublingual delivery because it directly enters your bloodstream. According to some research findings, the effects of liposomal NMN can take around three minutes and continue to rise with time. Some of the effects include but are not limited to improved cognitive function, and this shows that it affects blood flow to the brain.

What Are The Benefits Of NMN Supplementation?

Prolonged NMN supplementation has shown possibilities of improving vascular health and the immune system. In addition, it can boost energy levels and slow the aging process. Other potential benefits include helping with help with Alzheimer’s Disease and improving age-related blood-flow issues. However, you can use NMN as it improves lower blood pressure. Furthermore, it would be best if you had professional medical advice before using nicotinamide mononucleotide.

What Are The Signs That NMN Supplementation Is Working?

Some signs that NMN supplements are working include increased energy levels, improving muscle health, and lean muscle mass. These effects result from increased NMN, which increases nicotinamide adenine dinucleotide levels in your system. However, it will be best to take a NAD booster for around three months for noticeable change.

Can You Take NMN With Trimethylglycine (TMG)?

Yes, you can take NMN with TMG. It’s essential to do so because the increase in nicotinamide adenine dinucleotide production has the potential to drain the methyl available in your body. Supplementing Trimethylglycine ensures the availability of enough TMG to dispose of NAM. It will be best if you take two capsules of TMG in the morning or as per professional advice.

What Are The Possible Side Effects Of Taking NMN Supplements?

There have been reports of side effects such as headaches, nausea, vomiting, and dizziness, especially if taken on an empty stomach. NMN is safe if taken properly. Therefore, it will help if you follow professional medical advice and avoid suffering the side effects.

Conclusion: Which Brand Offers The Best NMN Supplement? 

The book by geneticist David Sinclair opened a gateway to such supplements. The book detailed how NMN can increase NAD levels, improve cellular health, and other health benefits. This led to an increase in the popularity of NMN among the elderly and middle-aged athletes. However, the popularity attracted supplement manufacturers, some of whom have questionable manufacturing practices.

To that end, we have compiled this guide for the best MNN supplements. We have covered the best NMN brands and factors to consider when buying NAD boosters. It will be best to use the information as you begin with such supplementation. Doing so will help you get the best NMN supplement and reap the health benefits. However, you should also maintain a proper diet that provides amino acids and essential vitamins as you use NMN anti-aging supplements.


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